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目的:制备槲皮素固体脂质纳米粒凝胶骨架缓释片,并对其释药影响因素及释药模型进行探讨。方法:采用高温乳化-低温固化制备槲皮素固体脂质纳米粒,并进一步制备成凝胶骨架缓释片。分别采用零级、一级、Higuchi及Ritger-Pappas方程,对槲皮素固体脂质纳米粒凝胶骨架缓释片的释药模型进行拟合。结果:槲皮素固体脂质纳米粒凝胶骨架缓释片体外释放行为符合零级释药模型,释药方程为:Mt/M∞=0.0783t+0.0394(r=0.9908)。释药机制以骨架溶蚀机制为主。结论:槲皮素固体脂质纳米粒凝胶骨架缓释片处方合理,制备工艺可行,在12 h内具有良好的体外缓释作用。
OBJECTIVE: To prepare quercetin solid lipid nanoparticle gel matrix sustained-release tablets, and to study its influencing factors and drug release model. Methods: Quercetin solid lipid nanoparticles were prepared by high-temperature emulsification-low temperature solidification and further prepared into gel matrix sustained-release tablets. The release models of quercetin solid lipid nanoparticle gel matrix sustained-release tablets were fitted using zero order, first order, Higuchi and Ritger-Pappas equations respectively. RESULTS: The in vitro release behavior of quercetin-loaded solid lipid nanoparticle gel matrix sustained-release tablets was consistent with the zero-order release model. The release equation was: Mt / M∞ = 0.0783t + 0.0394 (r = 0.9908). Drug release mechanism to skeleton dissolution mechanism. CONCLUSION: The formulation of quercetin solid lipid nanoparticle gel matrix sustained-release tablets is reasonable and the preparation process is feasible. It has a good in vitro sustained release effect within 12 h.