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本实验使用大鼠体外皮 -神经标本证明 ,施用外源性谷氨酸可以兴奋脚掌的伤害性感受器 ,并使其致敏。实验表明 ,经施用谷氨酸后 ,大多数的A型机械热刺激敏感纤维 (AMH)或C型机械热刺激敏感纤维 (CMH)对热刺激表现过敏。谷氨酸引起的对热刺激过敏与谷氨酸是否兴奋该纤维无关 ,也与热刺激在未施加谷氨酸时是否能兴奋该纤维无关。相反 ,AMH或CMH在施加谷氨酸后其机械感受阈值并未降低。本资料提示外周的谷氨酸受体在伤害性感受的传入阶段起作用 ,为治疗外周痛可能提示新的治疗思路。
In this experiment, rat dermal-neural specimens were used to demonstrate that the administration of exogenous glutamate stimulates the nociceptors of the soles and sensitizes them. Experiments show that after the administration of glutamic acid, most of the A-type mechanical thermal stimulation sensitive fibers (AMH) or C-type mechanical stimulation-sensitive fibers (CMH) are allergic to thermal stimulation. Glutamate-induced hypersensitivity to heat stimulation has nothing to do with whether glutamate stimulates the fiber or not with thermal stimulation whether the fiber can be excited without glutamate. In contrast, AMH or CMH had no reduction in mechanical threshold after administration of glutamate. This data suggests that peripheral glutamate receptors play a role in the afferent phase of nociception and may suggest new therapeutic options for the treatment of peripheral pain.