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目的:了解高海拔地区睡眠呼吸暂停低通气综合征患者(sleep apnea-hypopnea syn-drome,SAHS)临床发病特点及探讨相关危险因素。方法:分析2007年1月—2009年12月在我院就诊疑似SAHS患者979例的一般资料及夜间多导睡眠监测(PSG)指标。结果:①经PSG监测分析后确诊的SAHS成年患者890例,未确诊者89例;②男性SAHS患者40岁～组比重最高,女性50岁～组所占比例最高,男女之比达6.671;③随着病情加重夜间指端最低氧饱和度、睡眠中平均指氧饱和度逐渐降低;夜间血压逐渐上升;④随着病情加重夜间睡眠中微觉醒次数与累计缺氧时间明显增加;⑤颈围、体质指数、收缩压、缺氧时间与呼吸暂停关系最为密切。结论:高海拔地区PSG监测仍为诊断SAHS的金指标;肥胖、年龄、粗颈围是SAHS发病的高危因素,对于高发年龄段的肥胖、粗颈、高血压患者应高度怀疑SAHS,建议行PSG监测。而对于确诊的SAHS患者,除睡眠呼吸紊乱指数(AHI)的诊断指标外,夜间指端最低氧饱和度、累计缺氧时间也可在一定程度上说明病情的严重程度。
Objective: To investigate the clinical features of high-altitude sleep apnea-hypopnea syn-drome (SAHS) and explore the related risk factors. Methods: The data of 979 patients with suspected SAHS in our hospital from January 2007 to December 2009 were analyzed and the index of nighttime polysomnography (PSG) was analyzed. Results: ①The number of adult patients with SAHS confirmed by PSG monitoring was 890 cases, 89 cases were not diagnosed. ② The male SAHS patients had the highest proportion of 40-year-old group and the female 50-year-old group, with the highest ratio of male to female of 6.671 ; ③ As the condition aggravates the lowest oxygen saturation at night, the mean oxygen saturation in sleep decreases gradually; the nighttime blood pressure gradually increases; ④With the aggravating condition, the number of arousals and the cumulative hypoxia time increase significantly during nighttime sleepiness; Wai, body mass index, systolic blood pressure, hypoxia time and apnea most closely. CONCLUSIONS: PSG monitoring in high altitude area is still the gold index for diagnosis of SAHS. Obesity, age and thickening are the risk factors for the development of SAHS. SAHS should be highly suspected in obese, hypertrophic, hypertensive patients with high prevalence. PSG monitor. In addition to the diagnosis of SAHS patients, in addition to the diagnostic index of sleep apnea-hypopnea index (AHI), the night-time finger minimum oxygen saturation, cumulative hypoxia time can also explain the extent of the severity of the disease.