芫花萜是从植物药芫花根中提出的结晶。它可作为中期妊娠引产药,给药途径是羊膜腔内或外注入,剂量为0.07～0.08毫克。两种给药途径的引产有效率分别为98%及90%,都具有引产时间短、副反应小、安全等优点。我们对中期妊娠引产的孕妇,于羊膜腔外注药的前后测定了羊水内PGF(6例)及血清绒毛膜促性腺激素(10例)含量的变化,为芫花萜中期妊娠引产的作用机制研究提供了依据。对象与方法对象:孕18～22周需终止妊娠者。给药方法:将充盈注射用水无菌8号导尿管(或内径1毫米的塑料管)经宫颈插入宫腔内(羊膜腔外)达宫底部,插入的深度(厘米数)与孕周数相同。经导管注入芫花萜100微克(以注射用水稀释到8毫升)后,再注入注射用水1毫升,以便使药液全部推入宫腔,拔除导管。注药后孕妇平卧半小时。羊水抽取方法:局部麻醉下用羊膜腔穿刺术抽取2毫升羊水后,用直径1毫米、长35厘米导管,从穿刺针孔中插入羊膜腔(深度约20厘米左右,回抽羊水通畅、色清),拔出穿刺针,保留导管,将2毫升针筒接上导管外端,固定于腹壁。在注射芫花萜前及注射后第1、6小时、产程开始前3～6小时、产程开始及胎儿排出时抽取羊水(2毫升),羊水必须澄清,不能 Yuntan terpene is from the plant medicine presented in the roots of Daphne genkwa. It can be used as midwifery induction drug, the route of administration is injected into the amniotic cavity or outside, the dose of 0.07 ~ 0.08 mg. Induction of both routes of administration of effective rates were 98% and 90%, all with short induction of labor, side effects of small, safe and so on. In pregnant women who have induced labor during the second trimester of pregnancy, the changes of PGF (6 cases) and serum chorionic gonadotropin (10 cases) in amniotic fluid before and after amniotic fluid injection were determined to be the mechanism of labor induction Provided the basis. Subjects and Methods Subjects: 18 to 22 weeks of pregnancy need to terminate the pregnancy. Method of administration: Sterile Catheter No. 8 (or plastic tube with an inner diameter of 1 mm) filled with water for injection was inserted into the uterine cavity (outside the amniotic cavity) to the bottom of the uterus through the cervix, and the depth (cm) the same. After injecting 100 μg of gendanthenum into the catheter (diluted to 8 ml with water for injection), 1 ml of water for injection was injected into the uterine cavity to remove the catheter. Pregnant women after supine for half an hour after injection. Amniotic fluid extraction method: local anesthesia with amniocentesis 2ml amniotic fluid extraction, with a diameter of 1 mm, 35 cm long catheter, the puncture needle hole into the amniotic cavity (depth of about 20 cm, smooth pumping back amniotic fluid, color clear ), Pull out the needle, keep the catheter, connect the 2 ml syringe to the outer end of the catheter and fix it to the abdominal wall. Amniotic fluid (2 ml) should be drawn before amniotic fluid injection and before the first and sixth hour after injection, 3 to 6 hours before the onset of labor and at the beginning of labor and when the fetus is excreted. Amniotic fluid must be clarified and can not be