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为研究雷尼替丁预防和治疗高血压脑出血病人合并上消化道出血。将该院近年治疗的９７例高血压脑出血病人，按是否于入院后７２小时内使用雷尼替丁分为两组，治疗组６７例，入院后即开始每日静脉滴注雷尼替丁１５０ｍｇ。对照组３０例，除在入院７２小时内未使用雷尼替丁外，其他治疗与治疗组基本相同。治疗组发生上消化道出血２例（２．９％），对照组发生上消化道出血５例（１６．７％），两组在出血率上有显著差异（Ｐ＜０．０５）。共对４２例病人进行了胃液ｐＨ值监测，其中治疗组２９例，胃液平均ｐＨ值为５．６±０．７，对照组１３例平均ｐＨ值为３．５±０．４（Ｐ＜０．０５）。治疗组无因上消化道出血致死的病人，对照组１例病人因上消化道出血合并肺部感染死亡，两组间无显著差异（Ｐ＞０．０５）。本组结果提示，雷尼替丁预防上消化道出血可能是通过降低胃酸分泌这一机制发挥作用的。雷尼替丁对改善高血压脑出血病人的预后有辅助意义。
To study the prevention and treatment of ranitidine in hypertensive intracerebral hemorrhage patients with upper gastrointestinal bleeding. 97 cases of hypertensive intracerebral hemorrhage treated in the hospital in recent years were divided into two groups according to whether ranitidine was administered within 72 hours after admission or not. The treatment group received 67 daily intravenous drip infusion of ranitidine 150mg. Control group, 30 cases, except within 72 hours of admission did not use ranitidine, the other treatment and treatment groups were basically the same. There were 2 cases of upper gastrointestinal bleeding (2.9%) in the treatment group and 5 cases (16.7%) of upper gastrointestinal bleeding in the control group. There was significant difference in the bleeding rate between the two groups (P <0.05). A total of 42 patients were monitored for gastric pH, including 29 in the treatment group, 5.6 ± 0.7 in the gastric juice and 3.5 ± 0.4 in the control group (P <0) .05). One patient in the control group died of upper gastrointestinal hemorrhage with pulmonary infection. There was no significant difference between the two groups (P> 0.05). This group of results suggest that ranitidine to prevent upper gastrointestinal bleeding may be through the mechanism of reducing gastric acid secretion play a role. Ranitidine can improve the prognosis of patients with hypertensive intracerebral hemorrhage.