引言虽然青霉素的重新发现和临床应用的发展是在四十年代,但这类抗生素的构效关系是在六十年代才确定的.对头孢菌素这类五十年代发现的抗生素,时间差距被大大的缩短了,仅在发现后的十年里就获得了相当多的有关结构活性方面的数据.代表在β-内酰胺研究领域里最新发展的单酰胺菌素反映了当今抗生素研究技术.在1979年发现的 INTRODUCTION Although the rediscovery and clinical application of penicillin has progressed in the 1940s, the structure-activity relationship of such antibiotics was not established until the 1960s. The difference in time between antibiotics found in the 1950s, such as cephalosporins Greatly shortened and considerable data on the activity of the structure were obtained only ten years after its discovery Monoclonal antibiotics, which represent the latest development in the field of beta-lactam, reflect current antibiotic research techniques. Found in 1979