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目的探讨HLA基因连锁不平衡情况与婴幼儿血管瘤发病的相关性。方法 77例广西汉族婴幼儿血管瘤为实验组,并选择103例汉族健康正常儿童作为正常对照组,应用聚合酶链反应—序列特异性引物(PCR-SSP)法分析研究对象的HLA-DQA1,-DQB1基因位点的多态性。根据等位基因及单倍体情况分别进行两组间比较,分析血管瘤与HLA-DQA1,-DQB1等位基因及单倍体的相关性。结果与正常对照组相比,婴幼儿血管瘤组中HLA-DQA1*0102基因频率显著降低(P=0.003);单倍型HLA-DQA1*0401-DQB1*0301显著降低(P=0.008)。结论在广西地区的汉族人群中,HLA-DQA1*0102等位基因及单倍型HLA-DQA1*0401-DQB1*0301可能与该地区汉族婴幼儿血管瘤的遗传易感性相关联。
Objective To investigate the relationship between HLA imbalance and infantile hemangiomas. Methods Totally 77 Han infants with hemangiomas in Guangxi were enrolled as experiment group. 103 healthy Han children were selected as normal control group. PCR-SSP method was used to analyze HLA-DQA1, -DQB1 gene polymorphism. According to the alleles and haplotypes, the correlation between hemangiomas and HLA-DQA1 and -DQB1 alleles and haplotypes was analyzed. Results The frequency of HLA-DQA1 * 0102 gene in infantile hemangiomas was significantly lower than that in normal controls (P = 0.003). The haplotype HLA-DQA1 * 0401-DQB1 * 0301 was significantly decreased (P = 0.008). Conclusion HLA-DQA1 * 0102 alleles and haplotype HLA-DQA1 * 0401-DQB1 * 0301 may be associated with the genetic predisposition of infantile hemangiomas in Han ethnicity in Han population in Guangxi.