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目的:了解内蒙古自治区巴彦淖尔市农村中老年人抑郁的流行情况,并探讨砷中毒与抑郁的关系。方法:分别于2016年12月和2018年4月,对巴彦淖尔市45周岁及以上的农村中老年人进行一对一访谈式问卷调查,并对调查对象的抑郁情况、砷中毒患病情况进行分析。采用多因素logistic回归分析砷中毒与抑郁的关系。结果:共纳入870名巴彦淖尔市农村中老年人,抑郁检出率为15.3%(133/870)。砷中毒者178人,其中抑郁37人,检出率为20.8%;非砷中毒者692人,其中抑郁96人,检出率为13.9%。砷中毒、非砷中毒者抑郁检出率比较,差异有统计学意义(χn 2 = 4.67,n P = 0.030)。多因素logistic回归分析显示,经校正与抑郁相关的因素后砷中毒者发生抑郁的风险是非砷中毒者的1.8倍[调整后比值比(n AOR) = 1.8,95%置信区间(n CI):1.1 ~ 3.1,n P < 0.05]。n 结论:巴彦淖尔市农村中老年人抑郁检出率较高,砷中毒可能增加抑郁发生的风险。“,”Objective:To understand the prevalence of depression in rural middle-aged and elderly people in Bayannur City, Inner Mongolia Autonomous Region, and to explore the relationship between arsenism and depression.Methods:In December 2016 and April 2018, a one-to-one interview questionnaire survey was conducted among middle-aged and elderly people aged 45 and above in rural areas of Bayannur City, and their depression and arsenism were analyzed. Multivariate logistic regression was used to analyze the relationship between arsenism and depression.Results:A total of 870 rural middle-aged and elderly people in Bayannur City were included, and the detection rate of depression was 15.3% (133/870). The detection rates of depression in arsenism and non-arsenism were 20.8% (37/178) and 13.9% (96/692), respectively, the difference was statistically significant (χn 2 = 4.67, n P = 0.030). Multivariate logistic regression analysis after adjusting for factors associated with depression showed that people with arsenism were 1.8 times as likely to be depression compared to those without arsenism [adjusted odds ratio (n AOR) = 1.8, 95% confidence interval (n CI): 1.1 - 3.1, n P < 0.05].n Conclusion:The detection rate of depression among rural middle-aged and elderly people in Bayannur City is relatively high, and arsenism may increase the risk of depression.