论文部分内容阅读
目的:探讨血清降钙素原与支气管哮喘急性发作严重程度的关系以及在分级治疗中的指导意义。方法:选取128例支气管哮喘急性发作期患者,分为降钙素原指导用药组(实验组)64例和常规治疗组(对照组)64例,前者按血清降钙素原水平、后者按患者病情结合医师经验指导使用抗生素,采用Spearman秩相关分析血清降钙素原水平与支气管哮喘急性发作严重程度的相关性,采用卡方或t检验比较两组及不同严重程度亚组的抗生素使用情况及预后。结果:治疗前不同严重程度的支气管哮喘急性发作患者血清降钙素原水平差异具有统计学意义(均P<0.05),支气管哮喘急性发作严重程度与血清降钙素原水平呈正相关(r=0.882,P=0.004);总体实验组(χ2=4.238,P=0.040)和支气管哮喘急性发作重度实验组(χ2=5.397,P=0.020)的抗生素使用率显著低于其对照组;急性发作重度实验组的住院费用显著低于其对照组(t=-2.100,P=0.043)。结论:血清降钙素原水平检测对支气管哮喘急性发作严重程度分级和指导抗生素的合理应用具有重要意义,对于支气管哮喘急性发作重度患者,能显著降低其抗生素的使用率和住院费用。
Objective: To investigate the relationship between serum procalcitonin and the severity of acute exacerbation of bronchial asthma and its significance in the classification treatment. Methods: A total of 128 patients with acute exacerbation of bronchial asthma were divided into two groups: 64 patients in the procalcitonin group (experimental group) and 64 patients in the conventional treatment group (control group). The former was treated with serum procalcitonin The patient’s condition was combined with the experience of the doctors to guide the use of antibiotics. Spearman rank correlation analysis was used to analyze the correlation between serum procalcitonin level and the severity of acute exacerbation of bronchial asthma. Chi-square or t-test was used to compare the use of antibiotics between two groups and subgroups of different severity And prognosis. Results: The levels of procalcitonin in patients with acute exacerbation of bronchial asthma before treatment were significantly different (all P <0.05). The severity of acute exacerbation of bronchial asthma was positively correlated with serum procalcitonin (r = 0.882 , P = 0.004). The antibiotic use rate in the experimental group (χ2 = 4.238, P = 0.040) and the acute exacerbation of bronchial asthma group (χ2 = 5.397, P = 0.020) was significantly lower than that in the control group Group hospitalization costs were significantly lower than its control group (t = -2.100, P = 0.043). Conclusion: The detection of serum procalcitonin level is of great significance for grading the severity of acute exacerbation of bronchial asthma and guiding the rational use of antibiotics. It can significantly reduce the usage rate of antibiotics and hospitalization costs in patients with severe exacerbation of bronchial asthma.