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目的探讨乙型肝炎肝硬化失代偿期并发自发性细菌性腹膜炎(SBP)的相关危险因素,为临床预防提供依据。方法 276例乙型肝炎肝硬化腹水患者,其中126例并发SBP(SBP组),150例未并发SBP(非SBP组),对可能影响SBP的10种因素进行分析。结果 SBP与血清总胆红素水平升高、腹水总蛋白降低、腹水病程延长、合并上消化道大出血、脾脏厚度>4.0 cm及门静脉内径>1.5 cm等因素关系密切(P均<0.05)。结论对于有以上高危因素的乙肝肝硬化失代偿期患者,应高度警惕SBP的发生,采取相应措施积极防治SBP以改善患者预后。
Objective To investigate the risk factors associated with spontaneous bacterial peritonitis (SBP) in decompensated cirrhotic patients with hepatitis B and provide basis for clinical prevention. Methods A total of 126 patients with ascites due to hepatitis B cirrhosis were included in this study. 126 patients with SBP (SBP group) and 150 patients without SBP (SBP group) were included in this study. Ten factors that may affect SBP were analyzed. Results SBP and serum total bilirubin levels, ascites total protein decreased, prolonged ascites, combined with upper gastrointestinal bleeding, spleen thickness> 4.0 cm and portal vein diameter> 1.5 cm and other factors are closely related (P all <0.05). Conclusion For patients with decompensated hepatitis B cirrhosis who have the above risk factors, we should be highly alert to the occurrence of SBP and take appropriate measures to prevent and treat SBP actively so as to improve the prognosis of patients.