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研究证明 ,血小板衍化生长因子 (ＰＤＧＦ)及转移生长因子 β(ＴＧＦ β)在糖尿病肾病 (ＤＮ )的发生、发展中起着重要的介导作用 ,其在肾内的过分表达可刺激系膜细胞的增生及细胞外基质 (ＥＣＭ)的过度扩张 ,最后导致肾小球及间质的纤维化。本文用ＲＴ ＰＣＲ研究ＤＮ大鼠肾皮
Studies have shown that platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF beta) play an important mediating role in the development and progression of diabetic nephropathy (DN), and its over-expression in the kidney can stimulate mesangial cells Hyperplasia and excessive expansion of the extracellular matrix (ECM), eventually leading to glomerular and interstitial fibrosis. In this paper, DN rat renal dermis was studied by RT-PCR