洋地黄类制剂用于治疗充血性心力衰竭经历了两个世纪。在此期间,充血性心力衰竭的药物治疗经过几次较大的变革,然而,常用于改善心肌收缩功能障碍的药物亦即作用于充血性心力衰竭基本因素的药物至今仍是洋地黄类制剂。但此类药物的正性变力性作用较弱,且治疗量与中毒量相近,以至在治疗充血性心力衰竭时常可发生灾难性的毒性反应。洋地黄类制剂毒性反应的诊断较难。心脏病患者服用后可出现一些被认为是毒性反应的表现,与原有心脏病的症状不易区别。其毒性反应可以是心脏外的,也可以是心脏方面的,主要表现为心律失常。心 Digitalis preparations have been used to treat congestive heart failure for two centuries. During this period, several major changes have taken place in the treatment of congestive heart failure. However, drugs commonly used to ameliorate myocardial contractile dysfunction, ie, the basic factor in congestive heart failure, are still the digitalis preparations. However, such drugs have a weak positive inotropic effect and similar therapeutic amounts and toxicant levels, which can often lead to catastrophic toxic reactions in the treatment of congestive heart failure. Digitalis toxicity diagnosis of the preparation more difficult. Some heart attack patients may experience some toxic reactions, which are not easy to distinguish from the symptoms of the original heart disease. The toxic reaction can be extra-cardiac, it can be the heart, mainly as arrhythmia. heart