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目的探讨PAK4在绒毛膜癌中的表达及意义。方法选取2008年5月至2010年12月绒毛膜癌组织标本20例作为实验组,正常早孕(6-12周)绒毛组织标本36例作为对照组,应用免疫组化技术检测上述两组绒毛组织中PAK4的表达情况。结果免疫组化检测结果显示:PAK4蛋白的阳性染色主要定位于细胞滋养层细胞的胞质内;实验组PAK4蛋白的阳性染色较强,阳性表达率为70.00%(14/20),明显高于对照组的阳性表达率36.10%(13/36),差异有统计学意义(χ2=5.914,P=0.015)。结论 PAK4可能在绒毛膜癌的发生发展中起了重要作用。
Objective To investigate the expression of PAK4 in choriocarcinoma and its significance. Methods 20 cases of choriocarcinoma tissue samples from May 2008 to December 2010 were selected as the experimental group and 36 cases of normal early pregnancy (6-12 weeks) chorionic tissue samples were used as control group. Immunohistochemistry was used to detect the chorionic tissue in the above two groups In PAK4 expression. Results The results of immunohistochemistry showed that the positive staining of PAK4 protein mainly localized in the cytoplasm of cytotrophoblast cells. The positive staining of PAK4 protein in the experimental group was strong (70.00%, 14/20), which was significantly higher than that of PAK4 protein The positive rate of the control group was 36.10% (13/36), the difference was statistically significant (χ2 = 5.914, P = 0.015). Conclusion PAK4 may play an important role in the development of choriocarcinoma.