论文部分内容阅读
目的探讨血清胃蛋白酶原pepsinogenⅠandⅡ(PGⅠ、PGⅡ)含量及其比值(PGR)与胃癌的诊断及胃癌胃全切术后有无复发的关系。方法采用放射免疫分析法,检测正常对照组172例、术前胃癌患者93例、胃癌胃全切术后患者36例、胃癌胃全切术后随访无复发患者5例及术后复发患者23例的血清PGⅠ、PGⅡ的含量并计算PGR。结果术前胃癌患者与正常对照组相比PGⅠ、PGR明显降低(P<0.05),PGⅡ无明显差异;胃癌胃全切术后患者及术后无复发患者与正常对照组相比PGⅠ、PGⅡ显著降低(P<0.05);胃癌胃全切术后患者及术后无复发患者与术前胃癌患者相比PGⅠ、PGR明显降低(P<0.05);术后复发患者与无复发患者相比PGⅠ、PGⅡ显著升高(P<0.05)。结论血清PGⅠ、PGⅡ的含量及PGR的变化,对胃癌的早期诊断及胃癌胃全切术后有无复发的监测具有重要的临床意义。
Objective To investigate the relationship between serum pepsinogen Ⅰand Ⅱ (PGⅠ, PGⅡ) and its ratio (PGR) in the diagnosis of gastric cancer and the presence or absence of recurrence after gastric cancer total resection. Methods Radioimmunoassay was used to detect 172 cases of normal control group, 93 cases of preoperative gastric cancer, 36 cases of gastric cancer after total resection, 5 cases of non-recurrence after gastric total gasotomy and 23 cases of postoperative recurrence Of serum PG Ⅰ, PG Ⅱ content and calculate PGR. Results Compared with the normal control group, PGⅠ, PGR and PGⅡ in patients with preoperative gastric cancer were significantly lower (P <0.05) and PGⅡ were not significantly different; patients with postoperative gastric cancer and patients without recurrence had significantly higher PGⅠ and PGⅡ (P <0.05). Compared with patients with preoperative gastric cancer, the PGⅠ and PGR were significantly decreased in patients with gastric cancer after radical resection and without recurrence (P <0.05). Compared with non-recurrent patients, PGⅠ, PG Ⅱ was significantly increased (P <0.05). Conclusion Serum PG Ⅰ, PG Ⅱ levels and changes in PGR have important clinical significance in the early diagnosis of gastric cancer and the monitoring of the recurrence after gastric cancer resection.