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虽然对莽草酸(shikimic acid)的研究由来已久,但只是在陆续发现了具有生物活性的乙二醛酶Ⅰ抑制剂(glyoxalase Ⅰinhibitor 1)和二(口恶)霉素(dioxolamycin 2)等含莽草酸类母核的天然产物后,才有合成莽草酸衍生物进行生物活性研究的报道,即由莽草酸甲酯合成乙二醛酶Ⅰ抑制剂的类似物3。
Although studies on shikimic acid have been taking place for a long time, glyoxalase I inhibitor 1 and dioxolamycin 2 containing biologically active The natural product of the shikimic acid-like mother nucleus has been reported for its biological activity in the synthesis of shikimic acid derivatives, namely the analog of glyoxalase I inhibitor synthesized from methyl shikimic acid.