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目的观察血管紧张素转换酶抑制剂卡托普利与螺内酯联合治疗高血压性心力衰竭的疗效和安全性。方法选60例高血压性心力衰竭患者,给予口服卡托普利5~10 mg,3次/d,螺内酯20~40 mg,1次/d,观察血压和心功能的改善情况。结果全部患者降压有效率为90.0%;心功能改善情况总有效率93.3%,其中显效70.0%,有效23.3%,无严重不良反应。结论卡托普利与螺内酯联合治疗高血压伴心力衰竭有效。
Objective To observe the efficacy and safety of captopril, an angiotensin converting enzyme inhibitor, and spironolactone in the treatment of patients with congestive heart failure. Methods Sixty patients with essential hypertension were treated with captopril 5 ~ 10 mg, 3 times daily, spironolactone 20 ~ 40 mg once daily for improvement of blood pressure and heart function. Results The effective rate of all patients was 90.0%. The total effective rate of heart function improvement was 93.3%, of which 70.0% was markedly effective and 23.3% effective. No serious adverse reactions were observed. Conclusions Captopril and spironolactone are effective in treating hypertension with heart failure.