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目的:建立冠心苏合胶囊中土木香内酯和异土木香内酯的含量的测定方法。方法:采用聚乙二醇20 000(PEG-20M)毛细管柱,FID检测器,程序升温:初始温度190℃,保持30 min,以120℃.min-1的速率升温至240℃,保持5 min;进样口温度260℃;检测器温度280℃。结果:在该色谱条件下,土木香内酯在48.96～244.8 mg.L-1呈良好的线性关系,异土木香内酯在51.28～256.4 mg.L-1呈良好的线性关系。结论:本方法灵敏、准确、重复性好,可用于冠心苏合胶囊的质量控制。
Objective: To establish a method for the determination of eugenol and isocorodolactone in Guanxin Suhe capsule. Methods: PEG-20M capillary column and FID detector were used to program temperature: the initial temperature was maintained at 190 ℃ for 30 min and the temperature was increased to 240 ℃ at 120 ℃ .min-1 for 5 min ; Inlet temperature 260 ℃; detector temperature 280 ℃. Results: Under the chromatographic conditions, geranyllactone showed a good linear relationship between 48.96 and 244.8 mg.L-1, and the iso-civil costone showed a good linear relationship between 51.28 and 256.4 mg.L-1. Conclusion: The method is sensitive, accurate and reproducible. It can be used for quality control of Guanxin Suhe capsule.