论文部分内容阅读
细菌的失活酶或纯化酶对抗生素的失活作用、细胞外膜孔蛋白丢失或内膜激活抗生素流出系统的产生引起的抗生素摄取降低、PBP-2a新的青霉素结合蛋白的产生以及DNA旋转酶A或B亚基的变异引起的对抗生素的亲和性降低等均为目前细菌对抗菌药物新的耐药机理。本文就上述的耐药机理、多重耐药菌株的发展、耐药基因的起源和传播等问题作了详尽的阐说和综述,并对21世纪的细菌耐药性以及人们将作的努力作了展望。
The inactivation of antibiotics by bacterial inactivating enzymes or purified enzymes, the reduction of antibiotic uptake caused by the loss of extracellular membrane porins or the production of intimal-infused antibiotic effluents, the production of a new penicillin-binding protein of PBP-2a, and DNA gyrase A or B subunit mutation caused by reduced affinity for antibiotics and so on are the new bacterial resistance to antibacterial drugs new mechanism. In this paper, the mechanism of resistance, the development of multidrug-resistant strains, the origin and spread of drug-resistant genes and other issues made detailed elaboration and review, and 21st century bacterial resistance and efforts will be made Outlook.