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近几年来在嗜中性粒细胞极度减少的病人中应用粒细胞输注者显著增多,在输注过程中常发生肺浸润。本文介绍了美国西德尼的Farber肿瘤研究所自1976年7月至1979年6月,在93例病人中进行的593次粒细胞输注的经验。93例中,儿科病人54例,成人39例。原有疾病为急性白血病69例,淋巴瘤6例,再生障碍性贫血2例,恶性组织细胞增多症2例,实体瘤14例。输注粒细胞的适应症为革兰氏阳性脓毒症11例次,革兰氏阴性脓毒症33例次,霉菌性脓毒症4例次,严重感染39例次,单纯发热7例次,预防性1(?)例次。
In recent years there has been a significant increase in the use of granulocyte transfusions in patients with extremely reduced neutrophil infiltration, which often occurs during infusion. This article describes the experience of 593 granulocyte transfusions in 93 patients from July 1976 to June 1979 at the Farber Cancer Institute in Sidney, United States. Among 93 cases, 54 were pediatric patients and 39 were adults. The original disease was acute leukemia in 69 cases, 6 cases of lymphoma, 2 cases of aplastic anemia, malignant histiocytosis in 2 cases, 14 cases of solid tumors. Inflammatory granulocyte indications were Gram-positive sepsis in 11 cases, Gram-negative sepsis in 33 cases, mycotic sepsis in 4 cases, severe infection in 39 cases, simple fever in 7 cases Preventive 1 (?) Cases.