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本研究采用随机双盲交叉的方式,比较氟卡胺与奎尼丁控制阵发性房颤(PAF)的疗效和耐受性,并报道了长期随访(32个月)的临床转归。方法 19例PAF患者符合下列条件选为研究对象:(1)无瓣膜性心脏病和缺血性心脏病的证据;(2)血清甲状腺素水平正常;(3)无3秒以上窦性静止的ECG证据(静息或动态);(4)频繁的症状性PAF发作,每月>2
In this study, a randomized, double-blind crossover study was conducted to compare the efficacy and tolerability of flecainide and quinidine in the management of paroxysmal atrial fibrillation (PAF) and to report the clinical outcome of long-term follow-up (32 months). Methods Nineteen patients with PAF were enrolled as subjects under the following conditions: (1) evidence of valvular heart disease and ischemic heart disease; (2) normal levels of serum thyroxine; (3) sinusostatic no more than 3 seconds ECG evidence (resting or dynamic); (4) Frequent episodes of symptomatic PAF> 2 per month