在过去的十年中,人们对胰岛素依赖性糖尿病(Ⅰ型糖尿病)病因的认识有了许多转变。人们认为在胰岛素生成细胞(langerhans β细胞)的进行性损伤中,慢性自身免疫反应很可能起关键性作用。由于发现了循环的胰岛细胞胞浆抗体(cytoplasmic islet-cell antibody,ICA),从而改变了对该病病因的认识。ICA首先在伴有其它有关的(或相关的)自身免疫性内分泌缺陷 In the past decade there have been many changes in the understanding of the etiology of insulin-dependent diabetes mellitus (type 1 diabetes). Chronic autoimmune responses are likely to play a pivotal role in the progressive damage of insulin-producing cells (langerhans beta cells). The discovery of a circulating cytoplasmic islet-cell antibody (ICA) altered the understanding of the etiology of the disease. ICA is first associated with other related (or related) autoimmune endocrine defects