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采用ConA活化小鼠胸腺细胞法检测终末期肾病(ESRD)患者血清中IL-1的水平,并观察了ESRD患者血清对P388D1传代细胞株产生IL-1的诱导作用。结果发现:①ESRD患者血清中IL-1的水平明显升高;②ESRD患者血清能刺激P388D1传代细胞产生IL-1;③ESRD患者血清刺激P388D1传代细胞产生IL-1的水平与患者血清肌酐水平及血清β_2-MG水平均无明显的相关关系。
The level of IL-1 in sera of patients with end-stage renal disease (ESRD) was detected by ConA-activated mouse thymocytes and the induction of IL-1 production by the serum of ESRD patients on the P388D1 line was observed. The results showed that: (1) IL-1 levels in ESRD patients were significantly increased; (2) Serum of ESRD patients stimulated the production of IL-1 in P388D1 passage cells; (3) serum levels of IL-1 in serum of patients with ESRD stimulated P388D1 cells did not correlated with serum creatinine -MG levels were no significant correlation.