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目的:探讨妊娠晚期母儿维生素D水平与重度子痫前期(severe preeclamsia,SPE)的关系。方法:选取2011年10月~2013年2月在该院定期产检,符合重度子痫前期诊断标准的孕妇33例,为观察组;正常孕妇36例,为对照组。于分娩时分别抽取产妇肘上静脉血、脐静脉血各2 ml,采用酶联免疫吸附测定法(enzyme linked immunosorbent assay,ELISA)分别检测血清25-(OH)D水平。结果:观察组母血25-(OH)D水平(29.17±9.18)nmol/L与对照组母血25-(OH)D水平(44.14±16.30)nmol/L比较,差异有统计学意义(P<0.01);观察组脐血25-(OH)D水平(37.13±11.69)nmol/L与对照组脐血25-(OH)D水平(40.12±14.69)nmol/L比较,差异无统计学意义(P>0.05);正常孕妇和重度子痫前期孕妇25-(OH)D水平差异时,分娩孕周和胎儿出生体重比较,差异无统计学意义(P>0.05),正常孕妇和重度子痫前期患者分娩孕周和胎儿出生体重与新生儿脐血25-(OH)D水平间差异无统计学意义(P>0.05)。结论:妊娠晚期母血25-(OH)D水平的下降可能与重度子痫前期发病相关,但在脐血25(OH)D水平上重度子痫前期胎儿与正常妊娠胎儿无明显差异;妊娠晚期的母胎维生素D水平对分娩孕周和胎儿出生体重无明显影响。
Objective: To investigate the relationship between maternal vitamin D levels and severe preeclamsia (SPE) in late pregnancy. Methods: From October 2011 to February 2013, 33 pregnant women, who were regularly examined in the hospital and met the diagnostic criteria for severe preeclampsia, were selected as the observation group and 36 normal pregnant women as the control group. The elbow venous blood and umbilical cord blood were drawn 2 ml each during childbirth. Serum 25- (OH) D levels were measured by enzyme linked immunosorbent assay (ELISA). Results: The level of 25- (OH) D in the observation group was significantly higher than that in the control group (29.17 ± 9.18) nmol / L and 25- (OH) D level in the control group (44.14 ± 16.30) nmol / L <0.01). The level of 25- (OH) D in umbilical cord blood in observation group (37.13 ± 11.69) nmol / L was not significantly different from that in control group (40.12 ± 14.69) nmol / L (P> 0.05). There was no significant difference in gestational age and fetal birth weight between normal pregnant women and severe pregnant women with 25- (OH) D levels (P> 0.05), normal pregnant women and severe eclampsia There was no significant difference in gestational weeks and fetal birth weight between prenatal and neonatal umbilical blood 25- (OH) D levels (P> 0.05). Conclusion: The decrease of 25- (OH) D level in maternal blood in late pregnancy may be related to the incidence of severe preeclampsia, but there is no significant difference in the level of umbilical blood 25 (OH) D between preeclampsia and normal fetuses. In late pregnancy The level of mothers’ vitamin D had no significant effect on gestational age and birth weight.