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目的探讨利托君对习惯性流产患者妊娠结局的影响。方法选取2015年2月至2016年2月广东省兴宁市妇幼保健院收治的100例习惯性流产患者作为研究对象,随机分为对照组和观察组,各50例。对照组患者给予硫酸镁治疗,观察组患者接受利托君治疗,比较两组患者治疗后血清白细胞介素-8(IL-8)、白细胞介素-10(IL-10)水平以及调节性T细胞百分率。结果观察组患者血清IL-8水平显著低于对照组,IL-10水平显著高于对照组,差异均有统计学意义(均P<0.05);观察组患者调节性T细胞占外周血总淋巴细胞的百分率和调节性T细胞占外周CD4+细胞的百分率均显著高于对照组,差异均有统计学意义(均P<0.05)。结论利托君可以有效改善母胎界面的细胞因子平衡,有效维持其免疫耐受,从而避免习惯性流产发生,提高妊娠成功率。
Objective To investigate the effect of Rituximab on pregnancy outcome in patients with habitual abortion. Methods From January 2015 to February 2016, 100 cases of habitual abortion patients admitted to Xingning MCH Hospital of Guangdong Province were selected as study subjects and randomly divided into control group and observation group, with 50 cases in each group. Patients in the control group were treated with magnesium sulfate. Patients in the observation group were treated with ritodrine. The levels of serum interleukin-8 (IL-8), interleukin-10 (IL-10) and regulatory T The percentage of cells. Results The level of serum IL-8 in the observation group was significantly lower than that in the control group, and the level of IL-10 in the observation group was significantly higher than that in the control group (all P <0.05). In the observation group, the percentage of regulatory T cells in total lymphocytes The percentages of cells and percentage of regulatory T cells in peripheral CD4 + cells were significantly higher than those in control group (all P <0.05). Conclusions Ritodrine can effectively improve the balance of cytokine at maternal-fetal interface and effectively maintain its immune tolerance, thus avoiding habitual abortion and improving the success rate of pregnancy.