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目的:探讨新生儿水肿时体内抗利尿激素(ADH)的变化及其对临床治疗的指导意义。方法:选取本院2009年1月～2011年1月收治的新生儿窒息、败血症、肺炎等病程中出现水肿的40例患儿为治疗组,选取本科同期收住的20例新生儿羊水咽下患者作为对照组,治疗组按随机数字表随机分为利尿剂组和常规治疗组。治疗组于水肿时及水肿消退后,对照组于入院时采集静脉血检测血钠、血ADH值。记录常规治疗组与利尿剂组水肿持续的时间。结果:水肿组患儿水肿时血钠及血ADH值与对照组相比差异有统计学意义(P<0.01),水肿消退后血钠及血ADH值与对照组相比差异无统计学意义(P>0.05);水肿组患儿治疗前后自身血钠及ADH值有差异(P<0.01)。利尿剂组水肿持续的时间短于常规治疗组,两组间病程比较差异有统计学意义(P<0.05)。结论:新生儿水肿时,体内ADH增高,使用利尿剂能缩短水肿的持续时间。
Objective: To investigate the changes of anti-diuretic hormone (ADH) in neonates with edema and its clinical significance. Methods: Forty children with edema during neonatal asphyxia, sepsis and pneumonia admitted to our hospital from January 2009 to January 2011 were enrolled in this study. Twenty neonates with amniotic fluid swallowing Patients as a control group, the treatment group randomly divided into diuretic group random table and conventional treatment group. The treatment group in edema and edema subsided, the control group was collected at admission venous blood serum sodium, blood ADH values. Record regular treatment group and diuretic group edema duration. Results: The edema group edema, serum sodium and blood ADH values compared with the control group, the difference was statistically significant (P <0.01), edema subsided serum sodium and blood ADH values compared with the control group was no significant difference P> 0.05). There was significant difference in serum sodium and ADH before and after treatment in children with edema (P <0.01). Diuretic group edema duration is shorter than the conventional treatment group, the course of disease between the two groups showed statistically significant difference (P <0.05). Conclusion: Neonatal edema, ADH increased in vivo, the use of diuretics can shorten the duration of edema.