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前言盐酸喘通(C_(11)H_(16)ClNO·HCl·H_2O)为我院1972年有机化学教研室及附属药厂试制成功并投入生产的一种新止喘药,它是β受体作用剂类型的止喘药。对游离组织胺、乙酰胆碱等神经化学介质引起的支气管痉挛有良好的缓解作用,口服肠内吸收良好。主要用于支气管喘息、慢性肺气肿等。本品毒性很低,文献记载小鼠灌胃 LD_(50)≈550(506—600)mg/kg。经我院药理组实验,以小鼠尾静脉注射给药,LD_(50)=55.6mg/kg。
(C_ (11) H_ (16) ClNO · HCl · H_2O) is a new antiasthmatic drug which was successfully put into trial production in the Department of Organic Chemistry of our hospital in 1972 and its subsidiary pharmaceutical factory. It is a β receptor Anti-asthmatic agent type. On the free histamine, acetylcholine neurochemical mediators caused by bronchial spasm have a good relief, oral absorption of good enteral. Mainly used for bronchial wheeze, chronic emphysema and so on. This product is very low toxicity, documented in mice LD_ (50) ≈ 550 (506-600) mg / kg. Pharmacology group in our hospital experiments, mice were injected intravenously, LD_ (50) = 55.6mg / kg.