目的:观察血液灌流(HP)治疗急性百草枯中毒的临床效果,探讨其价值。方法:百草枯中毒患者22例,分为HP组14例和非HP组8例,均给予常规0.9%氯化钠溶液洗胃、20%甘露醇导泻、补液、对症等综合治疗,HP组在此基础上尽早给予HP治疗,对比观察2组的治疗效果。结果:HP组痊愈率、总有效率明显高于非HP组,有统计学意义(P<0.01),中毒后6h内与6h后行HP者治愈率统计学意义(P<0.01);HP组ARDS和MOF发生率及病死率明显低于非HP组,有统计学意义(P<0.01),存活病例平均住院时间明显低于非HP组,死亡病例平均生存时间明显高于非HP组,有统计学意义(P<0.01)。结论:HP是救治急性百草枯中毒的有效方法,尽早应用HP可明显提高急性百草枯中毒患者治愈率,降低死亡率、减少并发症,而且安全可靠,不良反应少。 Objective: To observe the clinical effect of hemoperfusion (HP) on acute paraquat poisoning and to explore its value. Methods: Twenty-two patients with paraquat poisoning were divided into HP group (n = 14) and non-HP group (n = 8). All patients were given routine 0.9% sodium chloride solution gastric lavage, 20% mannitol catharsis, On this basis, give HP treatment as early as possible and compare the treatment effect of the two groups. Results: The cure rate and total effective rate of HP group were significantly higher than those of non-HP group (P <0.01), and the cure rate of HP within 6h and 6h after poisoning was statistically significant (P <0.01); HP group ARDS and MOF incidence and mortality were significantly lower than non-HP group, with statistical significance (P <0.01), the average hospital stay in patients with survival was significantly lower than non-HP group, the average death time was significantly higher than non-HP group Statistical significance (P <0.01). Conclusion: HP is an effective method to treat acute paraquat poisoning. As soon as possible, HP can significantly improve the cure rate, reduce the mortality rate and reduce the complications of patients with acute paraquat poisoning. Moreover, it is safe and reliable with few adverse reactions.