Noise characteristic is one of the important factors to be considered during the design of a launch vehicle system. In this paper, the acceptance conditions for the external noise environment of the instrument cabin are given based on multi-source data, including the measured data of the launch vehicle lift-off noise, the mechanical environ-ment of the launch vehicle equipment, and the external noise environment of the instrument cabin deduced from empirical formula. Then an acoustic and vibration transfer model is established based on the response data of the in-strument equipment used to conduct measurements in the noise test reverberation room. By using an external noise environment and a transfer model, the response of the instrument and equipment for the acceptance condition can be obtained. The acoustic and vibration prediction technology introduced in this paper can provide technical support in the environmental prediction analysis of heavy launch vehicles for the future.