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目的:比较枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停的临床疗效。方法:以我院新生儿科2012年10月至2013年10月收治的32例呼吸暂停早产儿作为对照组,我院新生儿科2013年11月至2014年11月收治的32例呼吸暂停早产儿作为治疗组,两组患儿都在相同的基础治疗上,对照组给予氨茶碱治疗,治疗组给予枸橼酸咖啡因治疗,回顾性分析两组患儿的临床疗效,观察不良反应。结果:治疗组的临床总有效率为96.9%,高于对照组的75.0%,两组比较差异有统计学意义(P<0.05)。治疗组患儿在治疗期间无发生不良反应病例,对照组有2例患儿用药时出现烦躁、心率加快,停药后症状消失。结论:枸椽酸咖啡因治疗早产儿呼吸暂停安全,不良反应少,可作为治疗早产儿呼吸暂停的首选药物。
Objective: To compare the clinical efficacy of citrate caffeine and aminophylline in the treatment of apnea in preterm infants. Methods: Thirty-two cases of preterm infants with apnea who were admitted to Department of Neonatology from October 2012 to October 2013 in our hospital were selected as control group. 32 cases of apnea preterm infants admitted to neonatal department of our hospital from November 2013 to November 2014 The treatment group, both groups of children in the same basic treatment, the control group given aminophylline treatment, the treatment group was given citrulline caffeine, the clinical efficacy of two groups were retrospectively analyzed, adverse reactions were observed. Results: The total effective rate of the treatment group was 96.9%, which was higher than that of the control group (75.0%). There was significant difference between the two groups (P <0.05). In the treatment group, there were no cases of adverse reactions in the treatment group. Two cases in the control group had irritability, fasting heart rate and disappearance of symptoms after treatment. Conclusion: Citrulline caffeine is safe and safe for apnea in preterm infants. It can be used as the drug of choice for the treatment of apnea in premature infants.