溶瘤腺病毒是治疗肿瘤的一种有效工具,它能选择性地在肿瘤细胞内增殖、裂解肿瘤细胞,而对邻近正常细胞几乎没有影响。利用肿瘤或组织特异性启动子取代控制腺病毒复制必需基因E1A的启动子是构建溶瘤腺病毒的一个策略。现将对这一领域的研究进展进行综述。 Oncolytic adenovirus is an effective tool for tumor treatment. It can selectively proliferate and lyse tumor cells in tumor cells with almost no effect on neighboring normal cells. The use of tumor-specific or tissue-specific promoters to replace the promoters that control E1A, an essential gene for adenoviral replication, is a strategy for constructing oncolytic adenoviruses. The research progress in this field will now be reviewed.