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目的 探讨食管鳞癌细胞凋亡和增殖细胞核抗原的表达及其临床意义。方法 采用原位DNA末端标记法和免疫组化法分别检测 70例食管鳞癌的细胞凋亡和增殖细胞核抗原的表达情况 ,计算出凋亡指数和增殖指数。结果 凋亡指数及其与增殖指数的比值与肿瘤的病理分级和淋巴结转移密切相关 (P <0 .0 5 )。结论 食管癌的发生发展与细胞凋亡和增殖失控有关。
Objective To investigate the expression of esophageal squamous cell carcinoma cell apoptosis and proliferating cell nuclear antigen and its clinical significance. Methods The apoptosis and proliferating cell nuclear antigen expression of 70 esophageal squamous cell carcinomas were detected by in situ DNA end labeling and immunohistochemistry. The apoptosis index and proliferation index were calculated. Results Apoptosis index and its ratio to proliferation index were closely related to tumor grade and lymph node metastasis (P <0.05). Conclusion The occurrence and development of esophageal cancer are related to the uncontrolled apoptosis and proliferation.