本文对炔诺酮－α，β－聚（羟烷基）－ＤＬ－天冬酰胺进行了体外释放的研究，其中包括炔诺酮－α，β－聚（３－羟丙基）－ＤＬ天冬酰胺（ＮＥＴ－ＰＨＰＡ）和炔诺酮－α，β－聚（４－羟丁基）－ＤＬ－天冬酰胺（ＮＥＴ－ＰＨＢＡ）。实验结果表明，在药物接入量接近的情况下，悬臂的长短对药物释放有一定的影响，从释放１２０ｄ的情况来看，接入量为２４．０％的ＮＥＴ－ＰＨＰＡ的释放速率为０．２４μｇ－ＮＥＴ／ｍｇＰｏｌｙ·ｄａｙ：接入量为２０．１％的ＮＥＴ－ＰＨＢＡ的释放速率为０．３７μｇ－ＮＥＴ／ｍｇ－Ｐｏｌｙ·ｄａｙ． In this study, the in vitro release of norethindrone-α, β-poly (hydroxyalkyl) -DL-asparagine was studied, including norethindrone-α, β-poly Aspartame (NET-PHPA) and Norethindrone-α, β-poly (4-hydroxybutyl) -DL-asparagine (NET-PHBA). The experimental results show that the length of the cantilever affects the release of the drug to a certain extent when the amount of the drug is approached, and the release rate of NET-PHPA with the access amount of 24.0% from the release of 120d is 0 .24 μg-NET / mgPoly · day: The release rate of NET-PHBA with 20.1% access was 0.37 μg-NET / mg-Poly · day.