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大鼠一次气管注入50mg三氧化二钴混悬液4个月后,可见肺纤维化改变。大鼠在中毒柜自然吸入0.1mg/m~3三氧化二钴3个月后,未见各项观察指标有明显改变;浓度达0.7mg/m~3时,动物出现贫血、血清铜蓝蛋白和唾液酸含量增高,肺脏器系数增大,提示亚慢性吸入三氧化二钴可能致肺纤维化以及对血象产生影响。
After a rat tracheal injection of 50mg cobaltous oxide suspension 4 months, we can see changes in pulmonary fibrosis. Rats in the poisoning cabinet naturally inhaled 0.1mg / m ~ 3 after 3 months of cobaltous oxide, no observed indicators have changed significantly; concentration of 0.7mg / m ~ 3, the animals appeared anemia, serum ceruloplasmin And sialic acid content increased, lung coefficient increased, suggesting that sub-chronic inhalation of cobalt oxide may cause pulmonary fibrosis and blood effects.