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在改水防治干预前的地方性砷中毒病区各单位调查资料中，居民皮肤色素异常（躯干色素沉着、躯干脱色斑点）的检出率均随着水砷含量上升而增加，显示出明显的正相关关系，且可建立良好的定量用回归方程式。皮肤色素异常亦和居民砷中毒检出率呈现良好的定量关系。这两种色素异常和地方性砷中毒的另一重要指标一掌跖角化亦呈现密切正相关。此外，两种色素改变相互间亦有明显的正相关关系。因而显示出这两种色素异常在地方性砷中毒流行病学研究中也是很有用的指标，应作为地方性砷中毒流行病学调查中应用指标。
In the survey data of various units of endemic arsenism poisoning area before the intervention of water diversion, the detection rate of resident skin pigmentation abnormalities (trunk pigmentation, trunk bleaching spots) increased with the increase of water arsenic content, showing obvious Positive correlation, and can establish a good quantitative regression equation. Pigmented skin abnormalities also showed a good quantitative relationship with the detection rate of arsenic poisoning in residents. Another important indicator of these two pigment abnormalities and endemic arsenic poisoning, palmoplantar keratosis, also showed a close and positive correlation. In addition, there was also a clear positive correlation between the two pigment changes. Thus, these two pigment abnormalities are also useful indicators in endemic arsenism epidemiological studies and should be used as an indicator in the epidemiological investigation of endemic arsenism.