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目的探讨超重及肥胖人群中,血清脂联素、瘦素和肿瘤坏死因子α(TNF-α)水平及其影响因素。方法 52例正常体质量者和36例超重及肥胖人群,检测血糖、血脂、胰岛素、C肽、肿瘤坏死因子α、瘦素、脂联素。结果与正常体质量人群相比,超重及肥胖人群中血清瘦素水平升高(P<0.01),并与体质量指数正相关(r=0.474,P<0.01),体质量指数和女性是血清瘦素水平的独立影响因素。结论在超重及肥胖人群中,血清瘦素水平增高,并与体质量指数和女性相关。
Objective To investigate the serum levels of adiponectin, leptin and tumor necrosis factor α (TNF-α) and its influencing factors in overweight and obesity population. Methods 52 cases of normal body weight and 36 cases of overweight and obese people, blood glucose, blood lipids, insulin, C-peptide, tumor necrosis factor alpha, leptin, adiponectin. Results Serum leptin levels were significantly higher in overweight and obese subjects than in normal subjects (P <0.01), and positively correlated with body mass index (r = 0.474, P <0.01). Body mass index and serum Independent factors of leptin level. Conclusions Serum leptin levels are elevated in overweight and obese people, and are associated with body mass index and women.