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慢性肾功能衰竭(肾衰)的患者可有磷酸盐潴留、继发性甲状旁腺功能亢进(甲旁亢)及1,25-(OH)_2D减少等表现。为了研究氢氧化铝对这些病人的治疗作用,作者曾给予7例非透析的慢性肾衰患者口服大剂量氢氧化铝(15～18g/d),发现患者于治疗后血清磷由6.3±1.3降至3.7±0.5mg/dl(P<0.005),血清甲状旁腺素由2.87±1.64降至1.85±1.26ngEq/ml(P<0.02),血清1,25-(OH)_2D也由19.4±6.1降至11.4±4.3pg/ml(P>0.02)。但血铝浓度则由1.7±1.0升至3.6±1.5μg/dl(P>
Patients with chronic renal failure (renal failure) may have phosphate retention, secondary hyperparathyroidism (hyperparathyroidism) and 1,25- (OH) _2D reduction in performance. In order to investigate the therapeutic effect of aluminum hydroxide on these patients, the authors administered a large dose of aluminum hydroxide (15-18 g / d) to 7 non-dialysis chronic renal failure patients and found that serum phosphorus decreased from 6.3 ± 1.3 To 3.7 ± 0.5 mg / dl (P <0.005), serum parathyroid hormone decreased from 2.87 ± 1.64 to 1.85 ± 1.26 ngEq / ml (P <0.02), and serum 1,25- (OH) To 11.4 ± 4.3 pg / ml (P> 0.02). However, blood aluminum concentration increased from 1.7 ± 1.0 to 3.6 ± 1.5μg / dl (P>