目的:探讨缬沙坦对肾性高血压大鼠血管内皮细胞的保护作用。方法:包埋左肾制备高血压大鼠模型,给予缬沙坦治疗5周,尾容积法测动物血压,观察缬沙坦组与高血压组血压变化并应用多导电生理记录仪描记心电图,放免法测定各组血浆血管紧张素(angiotensin,AngⅡ)和内皮素(endothelin,ET-1)水平,硝酸还原酶法测定一氧化氮(nitric-oxide,NO)水平。结果:缬沙坦可使肾性高血压大鼠血压回降84%,血浆AngⅡ含量升高26.2%,NO含量升高64.4%,ET-1含量下降49.1%(P< 0.01)。缬沙坦组与高血压组心率变异各指标无明显差异(P>0.05)。结论:缬沙坦通过促进内皮细胞分泌NO,抑制内皮细胞分泌内皮素,对肾性高血压大鼠血管内皮细胞功能具有保护作用。 Objective: To investigate the protective effect of valsartan on vascular endothelial cells in renal hypertensive rats. Methods: The model of hypertensive rats was established by embedding the left kidney. Valsartan was given for 5 weeks. The blood volume was measured by tail volume method. The changes of blood pressure were observed in valsartan group and hypertension group. The electrocardiogram Methods The levels of plasma angiotensin (AngⅡ) and endothelin (ET-1) were determined in each group. The level of nitric oxide (NO) was determined by nitrate reductase method. Results: Valsartan decreased blood pressure 84%, plasma AngⅡ content 26.2%, NO content 64.4% and ET-1 content 49.1% (P <0.01) in renovascular hypertensive rats. Valsartan group and hypertension group heart rate variability of each index no significant difference (P> 0.05). CONCLUSION: Valsartan has a protective effect on the function of vascular endothelial cells in renal hypertensive rats by promoting the secretion of NO from endothelial cells and inhibiting the secretion of endothelin by endothelial cells.