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目的探讨无精子症和严重少精子症的遗传学因素。方法对确诊为无精子症或者严重少精子症患者进行外周血染色体核型分析。结果 113例标本共检出染色体异常核型42例,异常核型检出率为37.17%,检出染色体非整倍体7例,占检出异常核型的16.67%;检出染色体结构异常9例,占检出异常核型的21.4%;检出Y染色体多态26例,占检出异常核型的61.9%。结论染色体异常与无精子症或严重少精子症有密切的关系。
Objective To investigate the genetic factors of azoospermia and severe oligospermia. Methods Peripheral blood chromosomal karyotyping was performed on patients diagnosed as azoospermia or severe oligospermia. Results Totally 42 cases of chromosomal aberration karyotype were detected in 113 cases, the detection rate of abnormal karyotype was 37.17%. Seven cases of chromosomal aneuploidy were detected, accounting for 16.67% of the detected abnormal karyotype. The chromosomal abnormalities were detected 9 Cases, accounting for 21.4% of detected abnormal karyotype; Detected Y chromosome polymorphism in 26 cases, accounting for 61.9% of detected abnormal karyotype. Conclusion Chromosome abnormalities and azoospermia or severe oligospermia are closely related.