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目的探讨原发性中枢神经系统淋巴瘤(PCNSL]的临床表现、治疗及预后。方法对9例经病理证实的PCNSL患者临床资料进行回顾性分析。本组病例均行手术治疗,术后部分病人辅以放化疗治疗。结果本组存活时间6-38月,中位生存时间27月,死因为肿瘤复发、肺部感染、上消化道出血。结论PCNSL恶性程度较高,术前诊断困难,预后不良。手术活检证实诊断后的高剂量氨甲喋呤结合全脑放疗的综合治疗方案可以明显延长存活时间,但最佳的治疗方案及治疗剂量仍需进一步研究确定。
Objective To investigate the clinical manifestations, treatment and prognosis of patients with primary central nervous system lymphoma (PCNSL) .Methods The clinical data of 9 PCNSL patients confirmed by pathology were retrospectively analyzed.The patients in this group underwent surgical treatment and some patients Adjuvant radiotherapy and chemotherapy treatment.Results The survival time of 6 to 38 months, the median survival time of 27 months, the cause of death was tumor recurrence, pulmonary infection, upper gastrointestinal bleeding.Conclusion PCNSL higher malignancy, preoperative diagnosis is difficult, prognosis Poor biopsy confirmed after diagnosis of high-dose methotrexate combined with whole brain radiation therapy can significantly prolong the survival time, but the best treatment and dose needs further study to determine.