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目的:探讨纳络酮在急危重症抢救中的运用效果以及时效、量效和不同病理状态下的副作用。方法:317例急危重症患者按就诊时间随机分为对照组和用药组,其中用药组又分为规定量组和加大量组。观察两组临床抢救效果并进行统计学处理。结果:意识状态,用药组与对照组具有显著性差异(χ2=5.025,P<0.05),对休克、重度安定类中毒患者血压两组具有显著性差异(χ2=5.029,P<0.05),对急性脑损伤所致Cushing’sAction中呼吸、心率影响两组具有显著性差异(χ2R=8.2901,PR<0.01,χ2H=4.631,PH<0.05),对高血压患者在运用基础降压药后两组对血压影响无统计学差异(χ2=0.246,P>0.05),对意识状态改变规定用量组与加大量组无统计学差异(χ2=0.685,P>0.05)。结论:纳络酮作为一种非特异抢救用药是安全有效的。尤其是在恢复意识状态、解除呼吸和心血管抑制有着积极作用。并可能对继发性脑功能损伤和其它并发症的预防以及总的抢救预后有着重要意义
Objective: To investigate the effect of naloxone in the emergency treatment of acute critically ill patients, as well as the effects of aging, curative effect and side effects under different pathological conditions. Methods: A total of 317 acute and critically ill patients were randomly divided into control group and medication group according to the time of treatment. The medication group was divided into the prescribed dose group and the large dose group. Two groups of clinical salvage effect and statistical analysis. Results: There was significant difference between the two groups (χ2 = 5.029, P <0.05) in the state of consciousness, the medication group and the control group (χ2 = 5.025, P <0.05) Acute brain injury caused by Cushing’s action in the respiratory and heart rate of the two groups was significantly different (χ2R = 8.2901, PR <0.01, χ2H = 4.631, PH <0.05), hypertension in patients with basal antihypertensive drugs after two groups There was no significant difference in blood pressure (χ2 = 0.246, P> 0.05). There was no significant difference between the two groups (χ2 = 0.685, P> 0.05). Conclusion: Naloxone is safe and effective as a non-specific rescue medication. Especially in the recovery of the state of consciousness, lift the respiratory and cardiovascular inhibition has a positive effect. And may have implications for the prevention of secondary brain injury and other complications as well as for overall prognosis of salvage