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目的:分析糜烂性食管炎(EE)的可能危险因素,探讨EE的有关病因。方法:按照2006年中华消化学会制定的《中国胃食管反流病共识意见》诊断标准,运用病例对照研究方法,分别记录187例病例组和172例对照组吸烟史、饮酒史、非甾体类抗炎药物(NSAIDs)服用史、胆囊切除史、体质指数(BMI)、食管裂孔疝、幽门螺杆菌(HP)感染等,对两组病例分别进行了比较分析。结果:EE组患者饮酒、服用NSAIDs、膈疝和肥胖明显高于正常组(P<0.05),EE组患者感染HP低于正常组(P<0.05),胆囊切除、吸烟情况两组无明显差异(P>0.05)。结论:饮酒、长期服用NSAIDs、膈疝和肥胖与EE的发生有密切关系,吸烟、胆囊切除术与EE的关系不明确,HP感染与EE呈现负相关,且与EE的严重程度也呈负相关。
Objective: To analyze the possible risk factors of erosive esophagitis (EE) and to explore the etiology of EE. Methods: According to the Diagnostic Criteria of Consensus on Gastroesophageal Reflux Disease in 2006 set by the Chinese Society of Digestive Diseases, a case-control study was conducted to record the smoking history, alcohol consumption history, non-steroidal Anti-inflammatory drugs (NSAIDs) taking history, history of cholecystectomy, body mass index (BMI), hiatal hernia, Helicobacter pylori (HP) infection, the two groups of patients were compared. Results: The alcohol consumption, NSAIDs, diaphragmatic hernia and obesity in EE group were significantly higher than those in normal group (P <0.05). The infection of HP in EE group was lower than that in normal group (P <0.05), and there was no significant difference between the two groups in cholecystectomy and smoking P> 0.05). CONCLUSION: Long-term use of alcohol, long-term use of NSAIDs, diaphragmatic hernia and obesity are closely related to the occurrence of EE. Smoking, the relationship between cholecystectomy and EE are not clear, and HP infection is negatively correlated with EE and negatively correlated with the severity of EE.