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目的:研究PTEN、VEGF在子宫内膜样腺癌中的表达及其临床意义,探讨其与子宫内膜样癌发展及生物学行为的相关性。方法:收集92例子宫内膜病理标本,应用免疫组织化学法(SP法)检测PTEN及VEGF的表达情况。结果:PTEN和VEGF在子宫内膜良、恶性病变组织中的阳性表达率相比差异有统计学意义(P<0.05);在子宫内膜癌高中分化组与低分化组中阳性表达率相比差异有统计学意义(P<0.05);在无肌层浸润或浸润深度≤1/2组与浸润深度>1/2组中的阳性表达率相比差异有统计学意义(P<0.05);VEGF在无淋巴结转移的子宫内膜癌组织中及有转移中的阳性表达率相比差异有统计学意义(P<0.05);PTEN阳性表达率与VEGF阳性表达率呈现出负相关性(γ=-0.633,P<0.05)。结论:PTEN阳性表达与子宫内膜癌的组织学分级及肿瘤侵袭性呈负相关,VEGF阳性表达与子宫内膜癌的组织学分级、肿瘤侵袭性及淋巴结转移呈正相关;二者在子宫内膜癌发生和发展中呈拮抗作用,表达呈负相关。监测PTEN和VEGF的表达,可以作为判断肿瘤恶性程度的指标。
Objective: To investigate the expression of PTEN and VEGF in endometrioid adenocarcinoma and its clinical significance, and to explore its relationship with the development of endometrioid carcinoma and its biological behavior. Methods: 92 cases of endometrial pathological specimens were collected, the expression of PTEN and VEGF was detected by immunohistochemistry (SP method). Results: The positive rates of PTEN and VEGF in benign and malignant lesions of endometrium were significantly different (P <0.05). Compared with the positive rates of PTEN and VEGF in high and low differentiated endometrial carcinoma The difference was statistically significant (P <0.05). There was a significant difference in the positive expression rate between the group without infiltration or depth of infiltration ≤ 1/2 and the depth of invasion> 1/2 (P <0.05). There was a significant difference in the expression of VEGF in metastatic endometrial carcinoma without lymph node metastasis (P <0.05). The positive rate of PTEN was negatively correlated with the positive rate of VEGF (γ = -0.633, P <0.05). Conclusion: The positive expression of PTEN is negatively correlated with histological grade and invasiveness of endometrial carcinoma. The positive expression of VEGF is positively correlated with histological grade, invasiveness and lymph node metastasis of endometrial carcinoma. The occurrence and development of cancer were antagonistic, the expression was negatively correlated. Monitoring PTEN and VEGF expression can be used as an indicator of malignancy.