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Atalay B等人进行了一项研究,分析了磷酸二酯酶5抑制剂枸橼酸西地那非对脑血管痉挛和血管内皮细胞凋亡的影响。将24只家兔分成4组,第1组为非手术组,第2组为蛛网膜下腔出血脑血管痉挛组,第3组为服用西地那非的非手术组,第4组为蛛网膜下腔出血脑血管痉挛后服用西地那非组,3组,4组西地那非48h口服给药,剂量为0.7 mg/kg,3次/d。电脑图像分析各组基底动脉周径。用TUNEL方法评估两组蛛网膜下腔出血后血管内皮细胞凋亡程度。结果采用方差分析和配对t检验,P<0.05有显著性意义。组间基底动脉周径有
Atalay B et al. Conducted a study analyzing the effect of phosphodiesterase 5 inhibitor sildenafil on cerebral vasospasm and vascular endothelial cell apoptosis. 24 rabbits were divided into 4 groups, the first group was non-surgical group, the second group was subarachnoid hemorrhage cerebral vasospasm group, the third group was sildenafil non-surgical group, the fourth group was cobweb Subcapsular hemorrhage after cerebral vasospasm taking sildenafil group, 3 groups, 4 groups of sildenafil oral administration 48h, a dose of 0.7 mg / kg, 3 times / d. Computer image analysis of each group of basilar artery circumference. TUNEL method was used to evaluate the apoptosis of vascular endothelial cells after subarachnoid hemorrhage in both groups. Results using ANOVA and paired t test, P <0.05 was significant. The basilar artery circumference between the groups was