对２０２例各类乙型肝炎患者的血清进行了ＨＢＶ与ＨＤＶ感染标记物测定，结果表明：⑴ＨＤＶ感染率为２７２３％，以肝癌、肝硬化和重症肝炎检出率较高（分别为１００％、４８２８％、３３３３％），提示ＨＢＶ与ＨＤＶ合并感染或重叠感染时，可导致病情加重和感染的慢性化；⑵本文研究结果还揭示，ＨＢＶ与ＨＤＶ合并或重叠感染时，ＨＢＶ和ＨＤＶ可以共存，并无相互抑制现象；⑶３例ＨＤＶ感染者未检出ＨＢｓＡｇ，一方面因效价低于目前检测水平，另一方面认为只要ＨＤＶ—ＲＮＡ进入宿主细胞，即可进行ＲＮＡ复制和ＨＤＡｇ表达，不需要依赖嗜肝ＤＮＡ病毒，而由ＨＤＶ独立完成 HBV and HDV infection markers were detected in serum of 202 patients with various types of hepatitis B. The results showed that: (1) The infection rate of HDV was 2723%, and the detection rate of hepatocellular carcinoma, cirrhosis and severe hepatitis was higher (100 %, 4828%, 3333%), suggesting HBV and HDV co-infection or overlapping infection, can lead to aggravation and infection of chronic; ⑵ The results of this study also revealed that HBV and HDV combined or overlapping infection, HBV and HDV can coexist without mutual inhibition; ⑶ HBsAg was not detected in 3 cases of HDV infected patients, on the one hand because the titer was lower than the current detection level; on the other hand, RNA replication could be performed as long as HDV-RNA enters the host cell And HDAg expression, independent of hepadnavirus, independently by HDV