Russell曾建议,标志出血性休克的乳酸酸中毒是周围脏器缺血的结果。但并不清楚哪些脏器是导致血中乳酸盐聚积的主要来源。众所周知,动物在严重失血时,保持内环境稳定的反应是将非生命重要脏器,如骨骼肌、皮肤、肾脏及肠的血液分流至生命重要脏器,心脏和脑。若释放给脏器的氧不能满足其氧需时,则加速糖的酵解,酵解后的产物丙酮酸盐不能氧化,致使乳酸盐产物大大加速。休克时各脏器造成乳酸酸中毒的程度决定于血流减少的程度与其氧需之比。而骨骼肌乃组成机体的绝大部分体群,休克时血流急剧地减少,表明缺血的骨骼肌可能是导致出血性休克时产生乳酸的主要来源。然而作者以前的研究结果是,硫苯妥钠麻醉鼠在出血性休克各期,其比目鱼 Russell has suggested that lactic acidosis, a marker of hemorrhagic shock, is the result of ischemia in the surrounding organs. However, it is unclear which organs are the main source of lactate accumulation in the blood. It is well-known that in severe blood loss, animals maintain a stable internal environment by shunting vital non-vital organs, such as skeletal muscle, skin, kidneys and intestine, to important vital organs, heart and brain. If the oxygen released to organs can not meet its oxygen needs, then accelerate the glycolysis of glycolysis, the product of pyruvate oxidation can not be oxidized, resulting in greatly accelerated lactate product. Shock caused by the various organs of lactic acidosis depends on the degree of blood flow reduction and its oxygen ratio. Skeletal muscle, however, constitutes the vast majority of the body mass and drastically reduces blood flow during shock, indicating that ischemic skeletal muscle may be the main source of lactate during hemorrhagic shock. However, the author’s previous study results show that the rats in the sodium fluphenylate anesthesia during hemorrhagic shock, flounder