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应用β-肾上腺素能阻滞剂治疗青光眼,系近年来有效地控制眼压而又较少副作用的药物研究方面的一项主要进展。噻吗心安能有效地降低眼压,但由于无选择性地抑制β_1和β_2肾上腺素能受体,因此可能引起严重的全身副作用。而丙烯心安仅抑制β_1受体,因此副作用较少。本文采用前瞻性、随杋双盲法试验比较了丙烯心安与噻吗心安的作用和副作用。46例原发性开角型青光眼患者随机分为丙烯心安组35眼和噻吗心安组43眼。患者一眼或双眼眼压达26mmHg以上。每天早晚9点各点一次0.5％丙烯心安或噻吗心安,每次一滴。用药前了解患者病史、心
The use of beta-adrenergic blockers in the treatment of glaucoma is a major advance in the study of drugs that have been effective in controlling intraocular pressure with fewer side effects in recent years. Timofenac effectively reduces intraocular pressure but may cause severe systemic side effects due to the selective inhibition of beta 1 and beta 2 adrenergic receptors. Propranolol inhibits only the β 1 receptor and therefore has fewer side effects. In this paper, a prospective, double-blind test with shrews compared propylene and amphetamines and timolol effect and side effects. Forty-six patients with primary open-angle glaucoma were randomly divided into propofenan group 35 and timolol group 43 eyes. Patients with one eye or both eyes over 26mmHg. Every morning and evening at 9 o’clock each time a 0.5% propranolol or timolol, each drop. Understand the patient’s history before treatment, heart