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白细胞介素1(Interleukin 1简称IL-1)是一种肽类激素,在炎症及免疫反应中起着重要的信息传递和刺激细胞生长、分化的作用。由于肽类激素通常多是与有高度亲合力的膜受体的靶细胞相互作用而引起效应过程。估计IL-1也是经此途径而发挥作用,因此有关IL-1在细胞膜表面结合位点(受体)的研究是弄清IL-1如何发挥作用的关键。另外关于IL-1产生的机制,也就是刺激物作用于细胞膜之后引起一系列生化代谢变化,最终导致IL-1从细胞内释放出来这一过程的研究的关键在于IL-1的基因结构,定位与表达。上述有关IL-1的受体与基因是当前IL-1研究中的重要课题,是进一步取得IL-1研究中突破性进展的关键。
Interleukin 1 (IL-1) is a peptide hormone that plays an important role in the transmission of inflammatory and immune responses and stimulates cell growth and differentiation. Peptidic hormones often cause effector processes by interacting with target cells that are highly affinity membrane receptors. It is estimated that IL-1 also plays a role through this pathway, so the study on IL-1 binding sites (receptors) on the cell membrane surface is the key to clarifying how IL-1 functions. In addition, the mechanism of IL-1 production, that is, the stimulant acting on the cell membrane to cause a series of biochemical metabolic changes, and finally the key to the process of IL-1 release from the cell lies in the gene structure of IL-1. With expression. The above-mentioned receptors and genes related to IL-1 are important topics in the current study of IL-1 and are key to further progress in the breakthrough of IL-1 research.