1976年Borel在瑞士巴塞尔山都士药厂工作时,发现木霉菌Trichoderma pohysporum的培养液中有一种代谢产物,除有轻微抗菌作用外,还有强烈的免疫抑制作用,Dreyfus和Peteher证明这种代谢产物是由11个氨基酸组成的奇特的环状多肽结构物,其中有1个氨基酸是过去未曾见到过的。这多肽的分子量是1,203。不溶于水,易溶于油和酒精。命名为环孢霉素A(CyclosporinA,简写CSA)。 When Borel worked in 1976 in Basel Sands, Switzerland, he discovered that there was a metabolite in the culture fluid of Trichoderma pohysporum that had strong immunosuppressive effects in addition to mild antibacterial activity. Dreyfus and Peteher proved this The metabolite is a peculiar circular polypeptide structure composed of 11 amino acids, of which 1 amino acid has not been seen in the past. The polypeptide has a molecular weight of 1,203. Insoluble in water, soluble in oil and alcohol. Named Cyclosporin A (Cyclosporin A, abbreviated CSA).