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前列腺癌占临床癌肿的18%,为男性癌肿死亡的10%酮康唑(Ketoconazole)是一种咪唑衍化物,口服用于治疗各种霉菌,是睾丸及肾上腺类固醇合成的强力抑制剂,大剂量应用时可使睾丸酮量持续性降低.本文试图确定大剂量酮康唑对未经治疗的D～2期前列腺癌患者的疗效.
Prostate cancer accounts for 18% of clinical cancers and 10% of male cancer deaths. Ketoconazole is an imidazole derivative that is used orally to treat various molds. It is a potent inhibitor of testicular and adrenal steroid synthesis. The dose of testosterone can be reduced continuously at high doses. This article attempts to determine the efficacy of large doses of ketoconazole in untreated patients with stage D~2 prostate cancer.