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目的:探讨6种母子ABO血型不合的新生儿脐血血型血清学检验结果及临床型HDN发生率。方法:按检验操作规程对1199例母子ABO血型不合的新生儿脐血做血型血清学检验,在出生7天内分组调查其高胆红素血症发生率。结果:①母/子血型O/A(B)组合的新生儿抗体释放试验、DAT、IAT阳性率、临床型HDN发生率均极显著高于母/子血型A/B、A/AB、B/A、B/AB组合的新生儿(P<0.01)。②新生儿脐血血型血清学检验结果与临床型HDN发生率呈显著正相关性(P<0.01)。③患儿血液中存在的IgG抗-A+B对临床型HDN发生率无显著影响(P>0.01)。结论:ABO血型系统发生的临床型HDN以母/子血型O/A(B)组合的患儿为主(89.19%),母/子血型A/B、A/AB、B/A、B/AB组合的患儿较少(10.81%)。抗体释放试验阳性患儿血液中存在的游离抗体对判断患儿疾病的发展趋势有一定的意义。
Objective: To investigate the results of cord blood type serological tests and the incidence of clinical HDN in 6 neonates with different ABO genotypes. Methods: According to the test procedure, 1199 cases of neonatal umbilical blood with incompatible ABO blood group were analyzed by blood type serology, and the incidence of hyperbilirubinemia was investigated by grouping within 7 days of birth. Results: (1) Neonatal antibody release test, the positive rate of DAT, the positive rate of IAT and the incidence of clinical HDN were significantly higher than those of mother / child blood group A / B, A / AB, B / A, B / AB combination of newborns (P <0.01). (2) There was a significant positive correlation between neonatal umbilical blood group serological test and the incidence of clinical HDN (P <0.01). There was no significant effect of IgG anti-A + B in the blood of children on the incidence of clinical HDN (P> 0.01). CONCLUSIONS: The prevalence of clinical HDN in the ABO blood group is dominated by a combination of mother / child blood type O / A (B) (89.19%), mother / child blood type A / B, A / AB, B / A, B / AB combination of children less (10.81%). Antibody release test-positive children’s blood free antibodies exist to determine the development trend of children with disease has a certain significance.